Ionis Pharmaceuticals, Inc.

Fundamentals5.0
Price Action6.0
News Sentiment7.0
AI Rating
6.0

Key Drivers

  • Very high gross
  • Large operating losses
  • Extreme R&D intensity

AI
AI Summary

6.0

Ionis's shift from R&D to multi‑product commercialization means the investment hinges less on pipeline optionality and more on near‑term commercial execution and cash‑management (Can Tryngolza scale quickly enough to avoid dilutive refinancing?). Key actionable watchpoints: sustained quarterly revenue beats, clear payer agreements/pricing for core launches, and avoiding an external financing event in 2025.

Tryngolza
Refinancing
FDA‍

Price Chart

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Financial Metrics

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Revenue (TTM)
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Net Income (TTM)
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EPS (Q)
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MCAP

Deep Analysis

Research tool. Not personalized advice.

Fundamental Analysis

5.0

Key Financial Insights:

  • Very high gross
  • Large operating losses
  • Extreme R&D intensity

IONS has strong liquidity and exceptionally high gross margin but is loss-making with extreme R&D spend, high leverage, negative cash flow, and rich valuation that prices in future R&D success.

StrongLiquidity
HighLeverage

Price Behavior

6.0
Research tool. Not personalized advice. Technical analysis is for informational purposes only.

Key Price Behavior Insights:

  • Below last-month SMA
  • Low-$70s support
  • Tiered resistance

IONS is in a short-term downtrend—down ~14–15% over the last month, trading below the last-month SMA (~$76.8) with local support at $70–72 and resistance near $76.8 and $83–85; a sustained move above the SMA would be constructive, while a break below the low-$70s would extend the bearish case.

bearish
watch
Support Level: $70–72
Resistance Level: $76.8 and $83–85

~14–15% decline from $83.15 to $70.99 over the last month

Sentiment & News

7.0

Key News Insights:

  • Tryngolza upside
  • Mixed guidance
  • Insider selling

Ionis flagged stronger clinical and peak-revenue prospects (Tryngolza >$2B) and disciplined balance-sheet moves amid mixed near-term guidance and notable insider selling.

InsiderSales

Positive long-term revenue and cash-flow guidance support valuation upside, but near-term sentiment may remain pressured by conservative guidance and insider exits